You can make a difference by participating in a clinical trial. These are some of the many research studies that are being conducted here in Northeast Ohio. For more clinical trial information, see the links at the bottom of this page.

If you have questions about a particular study, please refer to the contact information provided with each listing.

• Type 2 Diabetes - over 50 years old, cardiovascular disease
      University Hospitals type 2 study.

• Type 2 Diabetes - Diagnosed before 18 years old
      DEFEND-2: Phase 3 Trial of Otelixizumab for Young Adults With Newly Diagnosed Type 1 Diabetes Mellitus.

• Type II Diabetes, History of Heart or Vascular Disease?
      Center for Vascular Health at St. Vincent Charity Hospital

• Painful Diabetic Neuropathy study - Cleveland Clinic
      Patients between 18 and 80 years old with pain in both feet

• Multiple clinical research trials
      Your Diabetes Endocrine Nutrition Group
  Multiple studies including the only remaining inhaled insulin in development. Participants will be compensated for their time and travel.

• Pregnancy study
      For women planning to become pregnant in the next year.

• LANCET Trial
      Participation and contact information
      Background and Eligibility
  The LANCET trial will investigate whether Lantus, a long-acting insulin injection, either alone or in combination with metformin, is effective in reducing C-reactive protein (CRP) in adults with type 2 diabetes. CRP is a marker of chronic low-level inflammation, a new risk factor for diabetes, heart attack, stroke, and other cardiovascular events.

• Diabetic Eye Disease/Macular Edema
      Treatment of Macular Edema - 4 studies

• Diabetes Management in Older Adults Study - Type 2 Diabetes
      Myers Research Institute of Menorah Park

• Medication Study - Type 2 Diabetes
      Cleveland Clinic Beachwood Family Health Center

• Heart attack, stroke, or vascular disease and high cholesterol
      St. Vincent Charity's The Center for Vascular Health - NIH AIM HIGH trial

• Foot Problems - Type 1 Diabetes
      BME Study

• Sleep Apnea
      Effects of Sleep Apnea Treatment on Metabolic Syndrome

• Diabetes - Gestational
      Diabetes in Pregnancy Study

• Diabetes - Type 1 or Type 2
      CRIC (Chronic Renal Insufficiency Cohort Study)

• Kidney Problems - Type 1 or Type 2 Diabetes
      CRIC (Chronic Renal Insufficiency Cohort Study)

• Pregnancy – Gestational Diabetes
      Diabetes in Pregnancy Study

For more information on clinical trials and to find comprehensive listings of northeast Ohio trials that are recruiting patients, visit the NIH Clinical Trials site (search "diabetes, Cleveland" or "diabetes, Akron", etc.) or the CenterWatch site (see Trial Listings/Endocrinology).

The NIH has a new site dedicated to research studies involving children. Children and Clinical Studies includes a list of questions for parents to consider asking the research team when deciding whether to enroll their child in a study. Other topics include:

• How institutional review boards monitor studies for safety
• Who's who on the research team
• Important terms to know, such as informed consent and assent
• How a child's participation in a research study can affect the entire family
• The rights of families enrolled in clinical studies